38page

Anti-Acne Clean Saver(PD) Sophora Flavescens Root Extract, Psoralea Corylifolia Fruit Extract, Platycarya Strobilacea Extract 1-3% Product Name_ INCI Name_ Dosage_ Clean Saver™ Sebum Change in Forehead Sebum Change in Cheek Anti-acne Effect – in vivo Evaluation Clean Saver2% 0 -5 -10 -15 -20 -25 -30 -35 δ(D28-D0)δ(D14-D0) S e b u m C h a n g e R a t e ( C h e e k , % ) Time (Day) Anti-bacterial Control of sebum 0 -5 -10 -15 -20 -25 -30 -35 δ(D28-D0)δ(D14-D0) S e b u m C h a n g e R a t e ( F o r e h e a d % ) Time (Day) Before After Clean Saver is a plant complex containing extracts from three plants, Sophora flavescens, Psoralea corylifolia and Platycarya strobilacea, which are all well-known oriental medicinal plants for anti-oxidant, anti-inflammatory, and anti-microbial ac tivities. Clean Saver shows anti-acne effect by decreasing the sebum release and by inhibiting the growth of Propionibacterium acnes , which is an aerotolerant anaerobic bacteria causing acne in skin. Story Action Mode of Clean Saver 18 male and female volunteers aged between 18 and 40 years old applied a cream containing 2% Clean Saver o n cheek and forehead for 28 days. Anti-acne Effect – in vivo Evaluation % o f C o n t r o l 120 100 80 60 40 20 0 0.5 1 2Control Concentration (%, v/v) Clean Saver Microbial (P. acnes) Growth Inhibition Activity Anti-acne Effect – in vitro Evaluation 1200 1000 800 600 400 200 0 D C F F l u o r e s c e n c e I n t e n s i t y 50403020 10 60 70 80 90 100 Time (Min) ROS Generation Inhibition Activity Anti-oxidant Effect – in vitro Evaluation 0.5% 1% 2%Control 38