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Soothing/Anti-inflammatory Portulaca Extract-TLS, Portulaca Extract-TLS(PD) Portulaca Oleracea Extract 1-3% Product Name_ INCI Name_ Dosage_ Portulaca Extract-TLS™ 6 5 4 3 2 1 0 D e r m a t o l o g i s t ' s S c o r i n g SLS Day 1 Day 3 Day 5 Day 7 Day 9 SLS Day 10 Time (Day) % o f C o n t r o l 450 400 350 300 250 200 150 100 50 0 D C F F l u o r e s c e n c e I n t e n s i t y 50403020 10 60 70 80 90 100 Time (Min) 300 250 200 150 100 50 0 E V a l u e SLS Day 1 Day 3 Day 5 Day 7 Day 9 SLS Day 10 Time (Day) 120 100 80 60 40 20 0 10 50 100Control Concentration (ppm ) Portulaca Extract-TLS Placebo Portulaca Extract-TLS Placebo 2 4 h S L S T r e a t m e n t Story Portulaca oleracea is an annual succulent with bright yellow flowers surrounded by a cluster of leaves. The p lant is known as purslane, little hogweed or pusly, and Machihyun in Korean meaning ‘horse teeth amaranth’ due to its resemblance to h orse’s teeth. It is an edible nutritious vegetable with a global distribution. It is well-known plant in Korean traditional medicine, generally used to treat infection and to relieve irritated skin. Clinical evaluation has shown that Portulaca Extract-TLS, an extract of P. olearacea, sho ws excellent skin soothing efficacy. ROS Generation Inhibition Activity Anti-oxidant Effect – in vitro Evaluation NO Synthesis Inhibition in Macrophages (RAW 264.7) Anti-inflammatory Effect – in vitro Evaluation On Day 0, patches containing 3% SLS solution were applied for 24 hours to induce erythema onto the forearms of 10 female volunteers aged between 18 and 65. On Day 9, erythema was re-induced by applying 3% SLS solution. A cream containing 2% Portulaca Extract-TLS was applied to the irritated skin twice a day for 10 days. Dermatologist’s Scoring Erythema Value Skin Soothing Effect – in vivo Evaluation 2 4 h S L S T r e a t m e n t 2 4 h S L S T r e a t m e n t 2 4 h S L S T r e a t m e n t 10ppm 50ppmControl NO Viability 30