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디자인팀 1월 3주차 주간업무입니다. Soothing/Anti-inflammatory Jeju Blossom(PD) Prunus Yedoensis Flower Extract 2-4% Product Name_ INCI Name_ Dosage_ Jeju Blossom™ On Day 0, patches containing 3% SLS solution were applied for 24 hours to induce erythema onto the forearm s of 10 female volunteers aged between 18 and 65. On Day 9, erythema was re-induced by applying 3% SLS solution. A cream contain ing 3% Jeju Blossom was applied to the irritated skin twice a day for 10 days. Dermatologist’s Scoring 7 6 5 4 3 2 1 0 D e r m a t o l o g i s t ' s S c o r i n g SLS Day 1 Day 3 Day 5 Day 7 Day 9 SLS Day 10 Time (Day) % o f C o n t r o l 120 100 80 60 40 20 0 0.5 1 2Control Concentration (%) Erythema Value 300 250 200 150 100 50 0 E V a l u e SLS Day 1 Day 3 Day 5 Day 7 Day 9 SLS Day 10 Time (Day) 800 700 600 500 400 300 200 100 0 D C F F l u o r e s c e n c e I n t e n s i t y 50403020 10 60 70 80 90 100 Time (Min) 2 4 h S L S T r e a t m e n t Story Jeju Blossom is a flower extract of Yoshino cherry (Prunus yedoensis) originally from Jeju Island in Korea. The fragrant, light pink flowers are known as ‘Jeju king cherry flowers’ and they bloom in April. Although the trees can be seen all over Jeju Is land, the full blossoms only last for a couple of days, and people celebrate this period during the Jeju Cherry Flower Festival. Jeju Blos som exhibits skin soothing effects through anti-inflammatory and anti-allergic actions. ROS Generation Inhibition Activity Anti-oxidant Effect – in vitro Evaluation NO Synthesis Inhibition in Macrophages (RAW 264.7) Anti-inflammatory Effect – in vitro Evaluation Skin Soothing Effect – in vivo Evaluation 2 4 h S L S T r e a t m e n t 2 4 h S L S T r e a t m e n t 2 4 h S L S T r e a t m e n t 0.5% 1% 2%Control NO Viability Jeju Blossom Placebo Jeju Blossom Placebo 29