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Soothing/Anti-inflammatory Everlotus® , Everlotus® (PD) Saussurea Involucrata Extract 1-3% Product Name_ INCI Name_ Dosage_ Everlotus® Story Saussurea involucrata, commonly known as snow lotus, is growing in high mountains in Himalaya and Central Asia. This rare alpine plant is capable of tolerating harsh environment and has high cold resistance. Snow lotus is a well-known medicinal herb in China for its anti-in- flammatory properties. Everlotus exhibits strong anti-oxidant, anti-wrinkle as well as anti-inflammatory activi ties. Molecular Structure of Rutin Collagen Synthesis Activity Anti-wrinkle Effect – in vitro Evaluation Everlotus® Anti-oxidant Anti-wrinkle Anti-inflammatory Properties of Everlotus® Active Compound of Everlotus® % o f C o n t r o l 100 80 60 40 20 0 0.63 1.25 2.50 5.000.31 Concentration (v/v, %) Everlotus DPPH Scavenging Activity Anti-oxidant Effect – in vitro Evaluation P I P ( % o f C o n t r o l ) 160 140 120 100 80 60 40 20 0 0.5 1 2Control Concentration (%, v/v) PIP Viability NO Synthesis Inhibition in Macrophages (RAW 264.7) Anti-inflammatory Effect – in vitro Evaluation % o f C o n t r o l 120 100 80 60 40 20 0 0.5 1 2Control Concentration (v/v, %) NO Viability O O O O O O HO OH OH OH OH OH OH HO HO HO H 3 C A U 0.00 0.50 1.00 1.50 2.00 2.50 3.00 5.00 10.00 15.00 20.00 25.00 30.00 35.00 40.00 45.00 50.00 55.00 60.00 Minutes Rutin 28