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Skin Brightening BDS-Perilla SPD Perilla Frutescens Extract 1-3% Product Name_ INCI Name_ Dosage_ BDS-Perilla™ A U 0.00 1.00 2.00 3.00 4.00 5.00 Minutes 5.00 10.00 15.00 20.00 25.00 30.00 35.00 40.00 45.00 50.00 55.00 ROS Generation Inhibition Activity Melanin Synthesis Inhibition in Melanocytes by BDS-Perilla Melanin Synthesis Inhibition in Melanocytes by rosmarinic acid 3000 2500 2000 1500 1000 500 0 D C F fl u o r e s c e n c e i n t e n s i t y Time (Min) Control 210.5 % o f C o n t r o l Concentration (%, v/v) 120 100 80 60 40 20 0 % o f C o n t r o l Concentration (ppm) 140 120 100 80 60 40 20 0 50403020 10 60 70 80 90 100 50 10010Control NO Synthesis Inhibition in Macrophages (RAW 264.7) Concentration (%, v/v) M e l a n i n I n d e x 190 185 180 175 22 female volunteers aged between 30 and 55 years old applied a cream containing 2% BDS-Perilla twice a day on face. Time(Day) Melanin Index Lightness Value Melanin Content Viability BDS-Perilla Placebo BDS-Perilla Placebo Melanin Content Viability D0 D28 D56 L V a l u e D i ff e r e n c e Time(Day) 0.6 0.5 0.4 0.3 0.2 0.1 0 δ(D28-D0) δ(D56-D0) Story Anti-oxidant Effect – in vitro Evaluation Anti-inflammatory Effect – in vitro Evaluation Active Compound of BDS-Perilla Perilla frutescens is a plant widely distributed and consumed in Asia where the leaves and the seeds are traditio nally used for both culinary and medicinal purposes. Phytochemical investigations identified rosmarinic acid as its main active constituen t responsible for anti-aller- gic and skin brightening actions. Other active compounds are found in P. frutescens including caffeic acid, perillic acid, and limonene. BDS-Perilla is the extract from the sprouts cultivated in a special facility, Bio-Dynamic Sprout (BDS) system. Skin Brightening Effect – in vitro Evaluation Skin Brightening Effect – in vitro Evaluation 1 20.5Control 120 100 80 60 40 20 0 % o f C o n t r o l NO Viability Skin Brightening Effect – in vivo Evaluation on Facial Dark Spot Area 0.5% 1% 2%Control Rosmarinic Acid 23