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Scoti-Speedwell(PD) Veronica Officinalis Extract 1-3% Product Name_ INCI Name_ Dosage_ Scoti-Speedwell™ * This is a product developed by the co-research project in associaton with the Royal Botanic Garden Edinburgh. Veronica officinalis, commonly called as speedwell, is an herbaceous perennial native to Europe. It is well-kn own for anti-inflammatory activity and used in herbal medicine for the treatment of eczema and wounds. In 19th century, speedwe ll has been used as a tea substitute in France where it was called “Europe tea” due to its bitter and astringent taste and tea-like s mell. Scoti-Speedwell is an extract of V. officinalis and shows anti-oxidant, anti-inflammatory and anti-wrinkle activities. Story Anti-oxidant Effect – in vitro Evaluation Anti-inflammatory Effect – in vitro Evaluation Anti-wrinkle Effect – in vitro Evaluation DPPH Scavenging Activity NO Synthesis Inhibition in Macrophages (RAW264.7) Collagen Synthesis Activity in Fibroblasts % o f C o n t r o l Concentration (%, v/v) 100 90 80 70 60 50 40 30 20 10 0 Scoti-Speedwell 1.60.4 0.80.2 % o f C o n t r o l Concentration (%, v/v) 120 100 80 60 40 20 0 NO 20.5 1Control Viability % o f C o n t r o l Concentration (%, v/v) 160 140 120 100 80 60 40 20 0 PIP 20.5 1Control Viability Anti-wrinkle Effect – in vivo Evaluation 18 female volunteers aged between 45 and 65 years old applied a cream containing 2% Scoti-Speedwell twice a day for 56 days to the eye contour area. Total Wrinkle Area Difference Wrinkle Length T o t a l W r i n k l e A r e a D i ff e r e n c e ( % ) D56D28D0 Time (Day) 110 105 100 95 90 85 80 75 70 65 60 Scoti-Speedwell Placebo Scoti-Speedwell Placebo W r i n k l e L e n g t h ( % ) D56D28D0 Time (Day) 110 105 100 95 90 85 Photograph Visualization Scoti-Speedwell 2% Before After Anti-aging 20