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Red Ginseng Active-R(PD) Panax Ginseng Root Extract 1-3% Product Name_ INCI Name_ Dosage_ Red Ginseng Active-R™ Anti-oxidant Effect – in vitro Evaluation As a representative medicinal herb in Traditional Korean Medicine, red ginseng has been used for many pur poses including promoting yang energy, improving circulation and in restoring balance. The color of red ginseng is obtained from a t raditional process which is repetitive steaming and drying of Panax ginseng root. The pharmacological activities are improved after this process by formation and accumulation of ginsenosides. Red Ginseng Active-R, an extract from 6-year-old Korean red ginseng, shows an ti-oxidant and anti-wrinkle activities as well as melanin synthesis inhibition activity. Story Analysis of ginsenosides in Red Ginseng Active-R DPPH Scavenging Activity Melanin Synthesis Inhibition in Melanocytes Skin Brightening Effect – in vitro Evaluation Collagen Synthesis Activity in Fibroblasts Anti-wrinkle Effect – in vitro Evaluation % o f c o n t r o l 1 20.5 Control 1 20.5 Control Concentration (%, v/v) 120 100 80 60 40 20 0 Melanin Content % o f C o n t r o l Concentration (%, v/v) 160 140 120 100 80 60 40 20 0 Cell Viability PIP Viability Anti-wrinkle Effect – in vivo Evaluation 21 female volunteers aged between 45 and 65 years old applied a cream containing 2% Red Ginseng Active-R twic e a day for 56 days on face. Total Wrinkle Area Difference Photograph Visualization T o t a l W r i n k l e A r e a D i ff e r e n c e ( % ) Time (Day) 105 100 95 90 85 80 75 70 65 60 Red Ginseng Active-R Placebo D0 D28 D56 Red Ginseng Active-R 2% Before After Anti-aging 3.13 6.25 12.51.56 % o f C o n t r o l Concentration (%, v/v) 80 70 60 50 40 30 20 10 0 Red Ginseng Active-R A U 0.02 0.04 0.06 Minutes 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 Rg1 Re Rb1 Rb2 Rg3 18